Maca root extract is known for its low glycemic index, which limits its impact on blood sugar. However, some studies have shown maca lowers or promotes healthy blood sugar. Maca has a long history of use in traditional medicine in South America and is known for everything from boosting libido to enhancing natural energy. Maca is the largest ingredient in Gluco Reverse. Some studies show the glucosinolates in maca, which are naturally present, could regulate insulin resistance and help with glucose metabolism.

Grape seed extract is the second-listed ingredient in Gluco Reverse’s proprietary formula, which means it’s the second-largest ingredient. Grape seed extract has been specifically studied for its effects on diabetes, with some studies linking grape seed to better postprandial blood glucose response. Some researchers believe these effects are linked to the natural resveratrol in grape seed extract, which appears to have antioxidant effects. Some also take grape seed extract daily for anti-aging effects.

Guarana, like maca, is known as a natural energy booster and is particularly popular in South America. It grows naturally in the Amazon. The same effects that boost natural energy in guarana could also help with blood sugar. According to some small studies, Guarana could help your body absorb sugar from your bloodstream. As WebMD explains, guarana primarily works because it contains caffeine, theophylline, and theobromine, all known for their ability to boost energy. In fact, guarana has more caffeine in terms of weight than coffee.

Some small animal trials have shown that African mango extract lowers abdominal fat and blood glucose levels. The fruit extract has surged in popularity in recent years after being used in traditional African medicine for centuries. Today, African mango extract has surged in popularity, particularly as a weight loss aid. Some small studies have linked African mango extract to a significant reduction in body weight.

Eleuthero is a root used for centuries in traditional Ayurvedic medicine as a stress reliever. Today, eleuthero continues to be popular as an adaptogen, and some use it daily for stress relief. According to WebMD, eleuthero could also lower blood sugar levels. In fact, WebMD cautions that eleuthero, when combined with blood sugar medication, could cause blood sugar to drop “too low,” which is why you should monitor blood sugar closely while taking eleuthero.

According to Mount Sinai, astragalus appears to lower blood sugar. Like eleuthero, astragalus is best known for its adaptogenic effects or stress-relieving properties, and some take it daily to help their bodies combat stress. Some believe astragalus works because of its natural antibacterial and antioxidant properties, which could help your body respond to inflammation.

Green tea is packed with catechins, or natural anti-inflammatory molecules, linked to various effects. Some take green tea daily for weight loss. Others take it for blood sugar control, inflammation, and general health. According to some trials, green tea has been shown to impact glucose control and insulin sensitivity. As Ohio State University explains, one recent study found green tea promoted gut health and lowered blood sugar, thereby lowering the risk of metabolic syndrome (i.e., diabetes).

Gymnema sylvestre is a plant extract used in traditional Indian medicine, including Ayurveda, for centuries. Today, it’s best known in the supplement industry for its effects on blood sugar. Some studies have linked gymnema sylvestre to anti-diabetic effects in rats—likely due to natural molecules called gymnemic acids within the plant. Some believe there’s a connection between gymnemic acids and obesity, with one study even describing the plant as having “potent anti-diabetic properties.”